Frontoparietal Structural Network Disconnections Correlate With Outcome After a Severe Stroke.

ABSTRACT: Structural disconnectome analyses have provided valuable insights into how a stroke lesion results in widespread network disturbances and how these relate to deficits, recovery patterns, and outcomes. Previous analyses have primarily focused on patients with relatively mild to moderate deficits. However, outcomes vary among survivors of severe strokes, and the mechanisms of recovery remain poorly understood. This study assesses the association between lesion-induced network disconnection and outcome after severe stroke. Thirty-eight ischaemic stroke patients underwent MRI brain imaging early after stroke and longitudinal clinical follow-up. Lesion information was integrated with normative connectome data to infer individual disconnectome profiles on a localized regional and region-to-regio

SUBMITTER: Frontzkowski L 

PROVIDER: S-EPMC11530704 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature