Ferritin adsorption onto chrysotile asbestos fibers influences the protein secondary structure.

ABSTRACT: Asbestos fiber exposure triggers chronic inflammation and cancer. Asbestos fibers can adsorb different types of proteins. The mechanism of this adsorption, not yet completely understood, has been studied in detail mainly with serum albumin and was shown to induce structural changes in the bound protein. The findings of these works regarded mainly the changes of the protein structure, independently of any relation with asbestos-related diseases. For the first time, we have focused our attention to the consequences of the interaction between asbestos fibers and ferritin, a protein involved in iron metabolism, which is strongly modified in asbestos-related diseases. Even if it is known that ferritin can be adsorbed by asbestos fibers, the results of this interaction for the ferritin secondary

SUBMITTER: Zangari M 

PROVIDER: S-EPMC11530830 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature