Flow Dynamic Factors Correlated With Device-Related Thrombosis After Left Atrial Appendage Occlusion.

ABSTRACT:

Background

Device-related thrombosis (DRT) occurs in up to 4% of patients undergoing left atrial appendage occlusion (LAAO) and is associated with substantial morbidity and mortality. However, its pathophysiology, predictors, and optimal management remain unclear.

Objectives

This study aims to assess flow dynamic factors correlating to DRT.

Methods

A multicenter registry of patients who underwent LAAO and had pre- and post-computed tomography imaging was used. Patient-specific 3-dimensional digital models of the left atrium were created, and finite element simulations were performed to implant an LAAO device into each model in a position that matched the clinical deployment. Computational fluid dynamic simulations were performed to quantify the following flow dynamic

SUBMITTER: Vogl BJ 

PROVIDER: S-EPMC11530902 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature