The role of NOP58 in prostate cancer progression through SUMOylation regulation and drug response.

ABSTRACT:

Background

Prostate cancer is one of the leading causes of cancer-related deaths in men. Its molecular pathogenesis is closely linked to various genetic and epigenetic alterations, including posttranslational modifications like SUMOylation. Identifying biomarkers that predict outcomes and specific therapeutic targets depends on a comprehensive understanding of these processes. With growing interest in SUMOylation as a mechanism affecting prostate cancer-related genes, this study aimed to investigate the central role of SUMOylation in prostate cancer prognostics, focusing on the significance of NOP58.

Methods

We conducted a comprehensive bioinformatics analysis, integrating differential expression analysis, survival analysis, gene set enrichment analysis (GSEA), and single-ce

SUBMITTER: Guo W 

PROVIDER: S-EPMC11530994 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature