Magnetic 3D macroporous MOF oriented urinary exosome metabolomics for early diagnosis of bladder cancer.

ABSTRACT: Bladder cancer (BCa) exhibits the escalating incidence and mortality due to the untimely and inaccurate early diagnosis. Urinary exosome metabolites, carrying critical tumor cell information and directly related to bladder, emerge as promising non-invasive diagnostic biomarkers of BCa. Herein, the magnetic 3D ordered macroporous zeolitic imidazolate framework-8 (magMZIF-8) is synthesized and used for efficient urinary exosome isolation. Notably, beyond retaining the single crystals and micropores of conventional ZIF-8, MZIF-8 is further enhanced with highly oriented and ordered macropores (150 nm) and the large specific surface area (973 m²·g^-1), which could enable the high purity and yield separation of exosomes via leveraging the combination of size exclusion, affin

SUBMITTER: Cao Y 

PROVIDER: S-EPMC11531116 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature