Complement proteins and complement regulatory proteins are associated with age-related macular degeneration stage and treatment response.

ABSTRACT:

Background

Dysregulation of the complement system is involved in development of age-related macular degeneration (AMD). The complement cascade is regulated by membrane bound complement regulatory proteins (Cregs) on mononuclear leukocytes among others. This study aims to investigate systemic complement proteins and Cregs in AMD stages and their association with treatment response in neovascular AMD (nAMD).

Methods

In this clinical prospective study, treatment-naïve patients with nAMD, intermediate AMD (iAMD) and healthy controls were recruited and systemic complement proteins C3, C3a and C5a were investigated with electrochemiluminescence immunoassays, and Creg expression (CD35, CD46 and CD59) on T cells (CD4 + and CD8+) and monocytes (classical, intermediate and non-classic

SUBMITTER: Thomsen AK 

PROVIDER: S-EPMC11531117 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature