Proton nanomodulators for enhanced Mn²⁺-mediated chemodynamic therapy of tumors via HCO₃^- regulation.

ABSTRACT:

Background

Mn²⁺-mediated chemodynamic therapy (CDT) has been emerged as a promising cancer therapeutic modality that relies heavily on HCO₃^- level in the system. Although the physiological buffers (H₂CO₃/HCO₃^-) provide certain amounts of HCO₃^-, the acidity of the tumor microenvironment (TME) would seriously affect the HCO₃^- ionic equilibrium (H₂CO₃ ⇌ H⁺ + HCO₃^-). As a result, HCO₃^- level in the tumor region is actually insufficient to support effective Mn²⁺-mediated CDT.

Results

In this study, a robust nanomodulator MnFe₂O₄@ZIF-8 (PrSMZ) with the c

SUBMITTER: Yang P 

PROVIDER: S-EPMC11531122 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature