Alterations of subcortical structure volume in pediatric bipolar disorder patients with manic or depressive first-episode.

ABSTRACT:

Background

Bipolar disorder may begin as depression or mania, which can affect the treatment and prognosis. The physiological and pathological differences among pediatric bipolar disorder (PBD) patients with different onset symptoms are not clear. The aims of the present study were to investigate subcortical structural alterations in PBD patients with first-episode depressive (PBD-FED) and first-episode manic (PBD-FEM).

Methods

A total of 59 individuals including 28 PBD-FED, 13 PBD-FEM, and 18 healthy controls (HCs) underwent high-resolution structural magnetic resonance scans. FreeSurfer 7.2 was used to detect changes in subcortical volumes. Simultaneously, thalamic, hippocampal, and amygdala subregion volumes were compared between the three groups.

Results

Analysis

SUBMITTER: Gao W 

PROVIDER: S-EPMC11531125 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature