Zero allergie research clinic: a clinical and research initiative in oral immunotherapy for managing IgE-mediated food allergy.

ABSTRACT:

Background and methods

The Zéro allergie research clinic (Saguenay, Canada) is a clinical and research initiative in oral immunotherapy (OIT) for managing IgE-mediated food allergy (FA). A total of 183 children with FA and 27 non-allergic siblings were recruited to date in the Zéro allergie cohort (ZAC) to better understand biological mechanisms underlying FA and OIT prognosis. The primary aims are to (a) better understand the genetic, epigenetic, transcriptomic, metabolomic, and microbial diversity associated with FA; (b) establish the multi-omics and microbial diversity profiles of children following OIT to identify predictive prognosis biomarkers, (c) make OIT more accessible to the population of the Saguenay-Lac-Saint-Jean region, and (d) build a biobank of data and biological

SUBMITTER: Tremblay BL 

PROVIDER: S-EPMC11531141 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature