The association between the triglyceride-glucose index and serum anti-aging protein α- Klotho: a population-based study.

ABSTRACT:

Background

Both anti-aging protein α-Klotho and the triglyceride-glucose (TyG) index hold predictive value for the incidence, progression, and outcomes of cardiovascular disease, diabetes and many other diseases. However, their relationship remains unclear.

Methods

We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2016. Weighted multivariate linear regression models and subgroup analysis were constructed to assess the association between TyG index and α-Klotho levels. Nonlinear correlations were explored using restricted cubic splines (RCS), generalized additive models (GAM) and smooth curve fitting. Segmented regression model was conducted to explore potential threshold effects and identify the inflect

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11531173 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature