Metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes: risk of heart failure.

ABSTRACT:

Background and aims

The association between metabolic dysfunction-associated steatotic liver disease (MASLD) and cardiovascular outcomes in patients with type 2 diabetes mellitus (T2DM) is unclear. This study aimed to investigate the impact of spectrum of SLD on the risk of heart failure and cardiovascular (CV) mortality in patients with T2DM.

Methods

In a nationwide cohort study, 2,745,689 adults with T2DM were followed from 2009 to 2012 until 2018. Participants were categorized into no steatotic liver disease (no SLD) and SLD groups. The SLD group was stratified based on metabolic risk factors, alcohol consumption and viral hepatitis. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for heart failure (HF) and CV m

SUBMITTER: Oh R 

PROVIDER: S-EPMC11531181 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature