Epigenetic signatures of asthma: a comprehensive study of DNA methylation and clinical markers.

ABSTRACT:

Background

Asthma, a complex respiratory disease, presents with inflammatory symptoms in the lungs, blood, and other tissues. We investigated the relationship between DNA methylation and 35 clinical markers of asthma.

Methods

The Illumina Infinium EPIC v1 methylation array was used to evaluate 742,442 CpGs in whole blood from 319 participants from 94 families. They were part of the Netherlands Twin Register from families with at least one member suffering from severe asthma. Repeat blood samples were taken after 10 years from 182 individuals. Principal component analysis on the clinical asthma markers yielded ten principal components (PCs) that explained 92.8% of the total variance. We performed epigenome-wide association studies (EWAS) for each of the ten PCs correcting for

SUBMITTER: Van Asselt AJ 

PROVIDER: S-EPMC11531182 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature