Optimization of fermentation conditions for physcion production of <i>Aspergillus chevalieri</i> BYST01 by response surface methodology.

ABSTRACT: This study aimed to optimize the culture conditions of the termite-derived fungus Aspergillus chevalieri BYST01 for the production of physcion, a characteristic component of the traditional herb rhubarb, which has been commercially approved as a botanical fungicide in China. First, potato dextrose broth was screened as the suitable basal medium for further optimization, with an initial yield of 28.0 mg/L. Then, the suitable carbon source, fermentation time, temperature, pH value, and the rotary shaker speed for physcion production were determined using the one-variable-at-a-time method. Based on the results of single factors experiments, the variables with statistically significant effects on physcion production were further confirmed using the Plackett-Burman design (PBD). Among th

SUBMITTER: Zhang S 

PROVIDER: S-EPMC11531253 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature