Tobacco use and psychosis risk in persons at clinical high risk.

ABSTRACT:

Aim

To evaluate the role of tobacco use in the development of psychosis in individuals at clinical high risk.

Method

The North American Prodrome Longitudinal Study is a 2-year multi-site prospective case control study of persons at clinical high risk that aims to better understand predictors and mechanisms for the development of psychosis. The cohort consisted of 764 clinical high risk and 279 healthy comparison subjects. Clinical assessments included tobacco and substance use and several risk factors associated with smoking in general population studies.

Results

Clinical high risk subjects were more likely to smoke cigarettes than unaffected subjects (light smoking odds ratio [OR] = 3.0, 95% confidence interval [CI] = 1.9-5; heavy smoking OR = 4.8, 95% CI = 1.7-13.7)

SUBMITTER: Ward HB 

PROVIDER: S-EPMC11531344 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature