Microbial transformation of dietary xenobiotics shapes gut microbiome composition.

ABSTRACT: Diet is a major determinant of gut microbiome composition, and variation in diet-microbiome interactions may contribute to variation in their health consequences. To mechanistically understand these relationships, here we map interactions between ∼150 small-molecule dietary xenobiotics and the gut microbiome, including the impacts of these compounds on community composition, the metabolic activities of human gut microbes on dietary xenobiotics, and interindividual variation in these traits. Microbial metabolism can toxify and detoxify these compounds, producing emergent interactions that explain community-specific remodeling by dietary xenobiotics. We identify the gene and enzyme responsible for detoxification of one such dietary xenobiotic, resveratrol, and demonstrate that this enzyme co

SUBMITTER: Culp EJ 

PROVIDER: S-EPMC11531382 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature