Phenotypic insights into genetic risk factors for immune-related adverse events in cancer immunotherapy.

ABSTRACT:

Background

Immune-related adverse events (irAEs) pose substantial challenges in the realm of cancer immunotherapy, frequently affecting treatment efficacy and patient safety. To address the urgent need for identifying risk factors associated with irAEs, we conducted a comprehensive phenotype-wide Mendelian randomization analysis (MR-PheWAS).

Methods

Utilizing publicly accessible genome-wide association study (GWAS) data, this investigation evaluated the impact of over 5000 exposure variables on susceptibility to irAEs using univariate Mendelian randomization (MR). We categorized these correlations and further explored potential mechanisms by which associated traits might influence irAEs through multivariate MR.

Results

MR-PheWAS identified numerous risk factors for ir

SUBMITTER: Ma H 

PROVIDER: S-EPMC11531409 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature