The causal relationship between anti-CD20 antibodies and endometrial cancer: a Mendelian randomization study.

ABSTRACT:

Purpose

To determine the effects of anti-B cell surface marker CD20 antibody on the occurrence and progression of endometrial cancer to provide insights into clinical treatment in the future.

Methods

We performed a two-sample Mendelian randomization analysis (MR) to analyze the causal relationship between EC and immune cell markers. The genome-wide association study (GWAS) data of MS4A1 single nucleotide polymorphism encoding gene of CD20 were collected, and a drug target MR analysis was performed to detect the causal relationship between anti-CD20 antibody and the risk of EC. The risk of follicular lymphoma was used as a positive control, and EC was used as the outcome.

Results

EC exerted an effect on 28 immunophenotypes, predominantly on CD20. CD20 in immunoglobulin

SUBMITTER: Su J 

PROVIDER: S-EPMC11531411 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature