In-vitro and In-silico evaluation of antimicrobial and antibiofilm effect of Neem oil and Calcium hydroxide nanoparticles against Mutans Streptococci and Enterococcus faecalis isolated from endodontic infections.

ABSTRACT: Different Streptococcal species including Streptococcus mutans, Streptococcus sobrinus and Enterococcus faecalis are commonly isolated in root canal infections including refractory, recurrent, and persistent cases. Calcium hydroxide (Ca (OH)₂) has been widely used in endodontics as an intracanal medicament. However, using new antimicrobial herbal alternatives offers promising potentials which can be additionally enhanced by using nanoparticles (NPs). In this study, we evaluate the antimicrobial efficacy and antibiofilm effect of Neem oil including its NPs preparations and we compare the effect of conventional Ca (OH)₂ to Ca (OH)₂ NPs using standard disc diffusion method and quantitative microtitre dish biofilm formation assay against common pathogens isolat

SUBMITTER: Nageeb WM 

PROVIDER: S-EPMC11531576 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature