It goes both ways: The relationship between anxiety and mild cognitive impairment.

ABSTRACT:

Objective

To investigate the relationship between anxiety and mild cognitive impairment (MCI), and whether it is mediated by perceived stress, at the population level.

Method and design

In a longitudinal study of 368 adults aged 65+ from a population-based cohort, we annually assessed anxiety symptoms (GAD-7), perceived stress (PSS-4), and ratings on the Clinical Dementia Rating (CDR®), where CDR = 0.5 was operationalized as MCI. Examining data from three consecutive assessment waves, we first determined the associations between anxiety at the first wave with MCI at the third wave, and vice versa. We then used mediation analyses to determine whether the pathways in both directions were mediated by perceived stress at the second wave, adjusting for demographics and other rele

SUBMITTER: Jain N 

PROVIDER: S-EPMC11531759 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature