Increased mortality in hospital- compared to community-onset carbapenem-resistant enterobacterales infections.

ABSTRACT:

Background

The CDC reported a 35% increase in hospital-onset (HO) carbapenem-resistant Enterobacterales (CRE) infections during the COVID-19 pandemic. We evaluated patient outcomes following HO and community-onset (CO) CRE bloodstream infections (BSI).

Methods

Patients prospectively enrolled in CRACKLE-2 from 56 hospitals in 10 countries between 30 April 2016 and 30 November 2019 with a CRE BSI were eligible. Infections were defined as CO or HO by CDC guidelines, and clinical characteristics and outcomes were compared. The primary outcome was desirability of outcome ranking (DOOR) 30 days after index culture. Difference in 30-day mortality was calculated with 95% CI.

Results

Among 891 patients with CRE BSI, 65% were HO (582/891). Compared to those with CO CRE, patient

SUBMITTER: Boutzoukas AE 

PROVIDER: S-EPMC11531819 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature