Activity of antibiotics against Burkholderia cepacia complex in artificial sputum medium.

ABSTRACT:

Background

Burkholderia cepacia complex (Bcc) is a collection of intrinsically drug-resistant Gram-negative bacteria that cause life-threatening disease in people with cystic fibrosis (CF). Standard antimicrobial susceptibility testing methods have poor predictive value for clinical outcomes in Bcc infections, probably due in part to differences between in vitro testing conditions and the environment in which Bcc grow in the lungs of people with CF.

Objectives

To compare the activity of commonly used antibiotics under standard in vitro testing conditions with activity in conditions mimicking those found in vivo.

Methods

Two Bcc strains were grown alone and with six different antibiotics (minocycline, ceftazidime, meropenem, tobramycin, levofloxacin, trimethoprim-sulfa

SUBMITTER: Shukla A 

PROVIDER: S-EPMC11531831 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature