Meso-cortical pathway damage in cognition, apathy and gait in cerebral small vessel disease.

ABSTRACT: Cerebral small vessel disease (SVD) is known to contribute to cognitive impairment, apathy and gait dysfunction. Although associations between cognitive impairment and either apathy or gait dysfunction have been shown in SVD, the inter-relations among these three clinical features and their potential common neural basis remain unexplored. The dopaminergic meso-cortical and meso-limbic pathways have been known as the important brain circuits for both cognitive control, emotion regulation and motor function. Here, we investigated the potential inter-relations between cognitive impairment, apathy and gait dysfunction, with a specific focus on determining whether these clinical features are associated with damage to the meso-cortical and meso-limbic pathways in SVD. In this cross-sectional stu

SUBMITTER: Li H 

PROVIDER: S-EPMC11531843 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature