Differential reorganization of episodic and semantic memory systems in epilepsy-related mesiotemporal pathology.

ABSTRACT: Declarative memory encompasses episodic and semantic divisions. Episodic memory captures singular events with specific spatiotemporal relationships, whereas semantic memory houses context-independent knowledge. Behavioural and functional neuroimaging studies have revealed common and distinct neural substrates of both memory systems, implicating mesiotemporal lobe (MTL) regions such as the hippocampus and distributed neocortices. Here, we explored declarative memory system reorganization in patients with unilateral temporal lobe epilepsy (TLE) as a human disease model to test the impact of variable degrees of MTL pathology on memory function. Our cohort included 31 patients with TLE and 60 age- and sex-matched healthy controls, and all participants underwent episodic and semantic retrieval

SUBMITTER: Cabalo DG 

PROVIDER: S-EPMC11531848 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature