Impact of maternal high-fat diet on offspring gut microbiota during short-term high-fat diet exposure in mice.

ABSTRACT: Alterations in the gut microbiome have been linked to obesity, with maternal high-fat diet (HF) playing a role in shaping offspring microbiome composition. However, the sex-specific responses to maternal HF diet and the impact of subsequent dietary challenges remain unclear. This study investigated the effects of maternal HF diet on offspring gut microbiota structure and predicted functional profile in response to short-term postnatal HF diet exposure with a focus on sex-specific responses. Female and male offspring of maternal control (C) diet or maternal HF diet were weaned onto C diet or HF diet. Offspring were euthanized at 13 weeks of age and cecal contents were collected for bacterial taxonomic profiling. Maternal HF diet reduced α-diversity, notably in male offspring weaned onto HF

SUBMITTER: Paz HA 

PROVIDER: S-EPMC11531878 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature