Real-world genome profiling in Japanese patients with pancreatic ductal adenocarcinoma focusing on HRD implications.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) poses significant challenges due to its high mortality, making it a critical area of research. This retrospective observational study aimed to analyze real-world data from comprehensive genome profiling (CGP) of Japanese patients with PDAC, mainly focusing on differences in gene detection rates among panels and the implications for homologous recombination deficiency (HRD) status. This study enrolled 2568 patients with PDAC who had undergone CGP between June 2019 and December 2021 using data from the nationwide Center for Cancer Genomics and Advanced Therapeutics database. Two types of CGP assays (tissue and liquid biopsies) were compared and a higher detection rate of genetic abnormalities in tissue specimens was revealed. HRD-related gene alteratio

SUBMITTER: Doi T 

PROVIDER: S-EPMC11531956 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature