Divergent transcriptomic profiles in depressed individuals with hyper- and hypophagia implicating inflammatory status.

ABSTRACT:

Background

Major Depressive Disorder (MDD) is a heterogenous and etiologically complex disease often presenting with divergent appetitive phenotypes including Hyperphagic MDD (characterized by an increased appetite) and Hypophagic MDD (characterized by a decrease in appetite) which are closely related to comorbidities, including cardiometabolic disorders. Hyperphagia is associated with atypical depression, decreased stress-hormone signaling, a pro-inflammatory status, hypersomnia, and poorer clinical outcomes. Yet, our understanding of associated biological correlates of Hyperphagic and Hypophagic MDD remain fragmented.

Methods

We performed an exploratory study on peripheral blood RNA profiling using bulk RNAseq in unmedicated individuals with Hyperphagic and Hypophagic MDD

SUBMITTER: Dan S 

PROVIDER: S-EPMC11532000 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature