Comparative analysis of In vivo endothelial cell translatomes across central nervous system vascular beds.

ABSTRACT: Endothelial cells (ECs) display organ- and tissue-specific heterogeneity. In the eye, the retinal and choroidal vascular beds are distinct networks with different molecular and morphological properties that serve location-specific functions, i.e., the former maintaining a tight barrier and the latter, a permeable fenestrated vasculature. Given that retinal health critically relies on the function of these vascular beds and that their dysfunction is implicated in a variety of retinal diseases, a molecular understanding of both physiological and pathophysiological characteristics of these distinct vasculatures is critical. Given their interspersed anatomic distribution among parenchymal cells, the study of EC gene expression, in vivo, has been hampered by the challenge of isolating pure popu

SUBMITTER: Chucair-Elliott AJ 

PROVIDER: S-EPMC11532013 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature