Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjogren's syndrome via suppression of the CX3CL1/CX3CR1 axis.

ABSTRACT:

Introduction

Primary Sjögren syndrome (pSS) is a systemic autoimmune disease that is characterized by the infiltration of immune cells into the salivary glands. The re-establishment of salivary glands (SGs) function in pSS remains a clinical challenge. Myeloid-derived growth factor (MYDGF) has anti-inflammatory, immunomodulatory, and tissue-functional restorative abilities. However, its potential to restore SGs function during pSS has not yet been investigated.

Methods

Nonobese diabetic (NOD)/LtJ mice (pSS model) were intravenously administered with adeno-associated viruses carrying MYDGF at 11 weeks of age. Salivary flow rates were determined before and after treatment. Mice were killed 5 weeks after MYDGF treatment, and submandibular glands were collected for analyses of h

SUBMITTER: Yang Z 

PROVIDER: S-EPMC11532040 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature