Quantification of muscle fiber malformations using edge detection to investigate chronic muscle pressure ulcers.

ABSTRACT:

Background

Microscopy of regenerated tissue shows different morphologies between the healing of acute wounds and chronic wounds. This difference can be seen manually by biologists, but computational methods are needed to automate the characterization of morphology and regenerative quality in regenerated muscle tissue.

Results

From the detected edge segments, we computed several imaging biomarkers of interest, such as median tortuosity, number of edge segments normalized by area, median edge segment distance and interquartile range of orientation angles of edge segments of the microscope images of successful and unsuccessful muscle regeneration. We observed that muscle fibers in saline-treated pressure ulcers had a larger interquartile range of orientation angles of the edge

SUBMITTER: Ong CZL 

PROVIDER: S-EPMC11532102 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature