Ubiquitin-proteasome system in <i>Plasmodium</i>: a potential antimalarial target to overcome resistance - a systematic review.

ABSTRACT:

Background

Malaria is a devasting parasitic disease that causes over half a million deaths every year. The necessity for prompt and thorough antimalarial drug discovery and development is accelerated by the rise in multidrug resistance and the lack of an effective vaccine. The Plasmodium spp. proteasome represents a prospective target for antimalarial treatment since several chemotherapy types have been shown to potently and selectively limit the growth of parasites. Combined with first-line artemisinin medicines, it creates synergy, even in the artemisinin-resistant parasites.

Methods

PRISMA guidelines were used in the development of this systematic review. A literature search was performed in March 2024 in PubMed, Science Direct, and Scopus databases, with the follo

SUBMITTER: Goncalves AF 

PROVIDER: S-EPMC11532105 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature