Hypertensive disorders of pregnancy and stroke: a univariate and multivariate Mendelian randomization study.

ABSTRACT:

Background

Hypertensive disorders of pregnancy (HDP) are associated with an increased risk of stroke later in life in multiparous women. However, causality of these associations remains unclear. This study employed 2-sample univariate and multivariate Mendelian randomization (MR) to assess the causal connection between HDP and stroke.

Methods

Genetic variants for HDP and two subtypes were identified from recent large-scale genome-wide association studies and the FinnGen consortium. Stroke summary data were obtained from the MEGASTROKE consortium. The primary analytical approach for univariate MR was the inverse variance weighting method. Sensitivity analyses incorporated methods such as MR-Egger regression, weighted median, and maximum likelihood to ascertain the robustness

SUBMITTER: Qu K 

PROVIDER: S-EPMC11532165 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature