Development of an alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell-derived liver organoids.

ABSTRACT: Alcoholic liver disease (ALD) poses a significant health challenge, so comprehensive research efforts to improve our understanding and treatment strategies are needed. However, the development of effective treatments is hindered by the limitation of existing liver disease models. Liver organoids, characterized by their cellular complexity and three-dimensional (3D) tissue structure closely resembling the human liver, hold promise as ideal models for liver disease research. In this study, we use a meticulously designed protocol involving the differentiation of human induced pluripotent stem cells (hiPSCs) into liver organoids. This process incorporates a precise combination of cytokines and small molecule compounds within a 3D culture system to guide the differentiation process. Subsequentl

SUBMITTER: Feng Z 

PROVIDER: S-EPMC11532202 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature