<i>Mycobacterium tuberculosis</i> evolution from monoresistance to pre-extensive drug resistance during a prolonged household outbreak.

ABSTRACT: Whole genome sequencing (WGS) is sensitive tool for the analysis of tuberculosis transmission and drug-resistance. We used WGS to analyze the Mycobacterium tuberculosis evolution from isoniazid monoresistance to MDR/preXDR during a prolonged household outbreak. The outbreak started with a isoniazid resistant strain (katG S315T mutation) and evolve in two cases to pre-XDR phenotype (with mutations in katG, rpoB, embB, pncA and gyrA genes). Based on WGS data and epidemiological interview we proposed a possible chain of transmission an evolution of the strains. Similar intra-patient and inter-patient acquisition of variability was observed, making difficult to distinguish reinfection or reactivation. Analysis of WGS data together with epidemiological clinical history are discussed in o

SUBMITTER: Greif G 

PROVIDER: S-EPMC11532306 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature