Oral N-acetylcysteine ameliorates liver fibrosis and enhances regenerative responses in Mdr2 knockout mice.

ABSTRACT: Cholangiopathies are poorly understood disorders with no effective therapy. The extrahepatic biliary tree phenotype is less studied compared to the intrahepatic biliary injury in both human disease and Mdr2^-/- mice, the established cholestatic mouse model. This study aimed to characterize the extra hepatic biliary tree of Mdr2^-/- mice at various ages and to determine if injury can be repaired with the antioxidant and glutathione precursor N-acetyl-L-Cysteine treatment (NAC). We characterized extra hepatic bile ducts (EHBD)s at various ages from 2 to 40 weeks old FVB/N and Mdr2^-/- mice. We examined the therapeutic potential of local NAC ex vivo using EHBD explants at early and late stages of injury; and systematic therapy by in vivo oral administration for 3

SUBMITTER: Har-Zahav A 

PROVIDER: S-EPMC11532366 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature