Does Fusobacterium in Colorectal Cancer Sites Originate From the Oral Cavity? A Pilot Study.

ABSTRACT:

Objectives

Fusobacterium can contribute to oral diseases, but also pose as a systemic risk factor. This genus, and especially F. nucleatum, can be found in colorectal cancer (CRC) tissue and is involved in multiple aspects of this type of cancer. Previous studies indicated a possible oral origin of these bacteria; however, stronger evidence is needed to reach a definitive conclusion. This pilot study aimed to establish a method to successfully compare, at the strain level, fusobacteria from the oral cavity and CRC resection material for future cohort studies of CRC patients.

Material and methods

In a first cohort of eight periodontitis patients, gingival crevicular fluid and saliva were collected. Fusobacterium was isolated on two different media. In a second cohort, saliva

SUBMITTER: Plomp N 

PROVIDER: S-EPMC11532368 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature