Identification of stable housekeeping genes in mouse liver for studying carbon tetrachloride-induced injury and cellular senescence.

ABSTRACT: Acute liver injury (ALI) presents a challenging problem worldwide, prompting extensive research efforts. Cellular senescence has been found to be induced following ALI, and targeting cellular senescence has shown therapeutic potential. Therefore, understanding the expression of senescence-related genes in ALI can help to explore pathogenesis and treatment of this common disease. Carbon tetrachloride (CCl₄) is commonly used to study ALI. Although polymerase chain reaction (PCR) is a convenient and economical molecular biology technique widely used in basic medicine, research on selecting suitable reference genes to obtain objective and reproducible PCR data is scarce. Moreover, evidence supporting the choice of reference genes for experimental studies of CCl4-induced ALI and hepa

SUBMITTER: He K 

PROVIDER: S-EPMC11532458 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature