Distribution and diversity of classical deacylases in bacteria.

ABSTRACT: Classical Zn²⁺-dependent deac(et)ylases play fundamental regulatory roles in life and are well characterized in eukaryotes regarding their structures, substrates and physiological roles. In bacteria, however, classical deacylases are less well understood. We construct a Generalized Profile (GP) and identify thousands of uncharacterized classical deacylases in bacteria, which are grouped into five clusters. Systematic structural and functional characterization of representative enzymes from each cluster reveal high functional diversity, including polyamine deacylases and protein deacylases with various acyl-chain type preferences. These data are supported by multiple crystal structures of enzymes from different clusters. Through this extensive analysis, we define the structural r

SUBMITTER: Graf LG 

PROVIDER: S-EPMC11532494 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature