Association of cumulative methylprednisolone dosages with mortality risk from pneumonia in connective tissue disease patients.

ABSTRACT: Corticosteroid is essential in the treatment regimen for connective tissue disease (CTD); however, its long-term use poses significant risks, including pulmonary infections. The relationship between cumulative corticosteroid doses and adverse pneumonia outcomes requires further investigation. This study aimed to explore the association between cumulative methylprednisolone dosages (CMD) and pneumonia mortality risks among CTD patients. We conducted a retrospective analysis of data from CTD patients treated with intravenous or oral corticosteroids across six academic hospitals over approximately five years in China. We evaluated follow-up outcomes at 30 and 90 days after the onset of pneumonia. Piecewise linear regression, Cox regression analysis, and survival analysis were employed to inve

SUBMITTER: Wang S 

PROVIDER: S-EPMC11532547 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature