Embryonic size and growth and adverse birth outcomes: the Rotterdam Periconception Cohort.

ABSTRACT:

Study question

Is early embryonic size and growth in the first trimester of pregnancy associated with adverse birth outcomes?

Summary answer

Larger embryonic crown-rump length (CRL) and embryonic volume (EV) are associated with lower odds of adverse birth outcomes, especially small for gestational age (SGA).

What is already known

Preterm birth, SGA, and congenital anomalies are the most prevalent adverse birth outcomes with lifelong health consequences as well as high medical and societal costs. In the late first and second trimesters of pregnancy, fetuses at risk for adverse birth outcomes can be identified using 2-dimensional ultrasonography (US).

Study design, size, duration

Between 2009 and 2018, singleton pregnancies were enrolled in this ongoing prospecti

SUBMITTER: Roelants JA 

PROVIDER: S-EPMC11532603 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature