Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity.

ABSTRACT: Progressive decline of the adaptive immune system with increasing age coincides with a sharp increase in cancer incidence. In this study, we set out to understand whether deficits in antitumor immunity with advanced age promote tumor progression and/or drive resistance to immunotherapy. We found that multiple syngeneic cancers grew more rapidly in aged versus young adult mice, driven by dysfunctional CD8+ T-cell responses. By systematically mapping immune cell profiles within tumors, we identified loss of tumor antigen-specific CD8+ T cells as a primary feature accelerating the growth of tumors in aged mice and driving resistance to immunotherapy. When antigen-specific T cells from young adult mice were administered to aged mice, tumor outgrowth was delayed and the aged animals became sens

SUBMITTER: Georgiev P 

PROVIDER: S-EPMC11532741 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature