Identification of genes related to fatty acid metabolism in type 2 diabetes mellitus.

ABSTRACT:

Aim

Fatty acid metabolism is pivotal for lipid synthesis, cellular signaling, and maintaining cell membrane integrity. However, its diagnostic significance in type 2 diabetes mellitus (T2DM) remains unclear.

Materials and methods

Three datasets and fatty acid metabolism-related genes were retrieved. Differential expression analysis, WGCNA, machine learning algorithms, diagnostic analysis, and validation were employed to identify key feature genes. Functional analysis, ceRNA network construction, immune microenvironment assessment, and drug prediction were conducted to explore the underlying molecular mechanisms.

Results

Six feature genes were identified with strong diagnostic performance and were involved in processes such as ribosome function and fatty acid metabolis

SUBMITTER: Yang J 

PROVIDER: S-EPMC11532806 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature