Middle-aged dogs with low and high Aβ CSF concentrations show differences in energy and stress related metabolic profiles in CSF.

ABSTRACT:

Background

Amyloid beta (Aβ) accumulation in the brain is one of the earliest findings in Alzheimer's disease (AD). The dog is a natural animal model for amyloid processing and early brain amyloid pathology. The goal of this study is to examine which differences in metabolomic profiles in cerebrospinal fluid (CSF) could be detected in dogs with a difference in CSF Aβ concentrations before amyloid accumulation occurs.

Method

Metabolic profiling was performed on CSF from 4 to 8 year old dogs with different CSF Aβ concentrations.

Results

Metabolomic profiling of CSF showed differences in brain energy metabolism. More specifically, increases in N-acetylation of amino acids and amino sugars, creatine and pentose metabolism, and a decrease in tricarboxylic acid (TCA) cycle

SUBMITTER: Borghys H 

PROVIDER: S-EPMC11532822 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature