Biological activity and characterization of leaf and seed lectins from <i>Terminalia brownii:</i> Insights into their analgesic and antiulcer properties.

ABSTRACT: Terminalia brownii Fresen, an African medicinal plant, is known for its analgesic, antiulcer, and antimicrobial properties, with its leaves, bark, and fruits deeply ingrained in indigenous healing practices. Two lectins, TerBLL (from leaves) and TerBSL (from seeds) of Terminalia brownii Fresen, were purified using salting-out and affinity chromatography on a fetuin-agarose column. The purified lectins were then assessed for protein yield, hemagglutination activity, and physicochemical properties. Both TerBLL and TerBSL have subunits with molecular weights of 57.3 and 65.7 kDa, respectively. TerBLL remains stable at 60-80 °C and is activated by Mn⁺², while TerBSL is activated by Zn⁺². These lectins maintain consistent activity under acidic conditions, wit

SUBMITTER: Idries AH 

PROVIDER: S-EPMC11532835 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature