Hsa_circ_0004194 suppresses colorectal cancer progression via hsa-miR-27a-3p.

ABSTRACT:

Aims

To investigate the functional role and the underlying molecular mechanisms associated with hsa_circ_0004194 in the context of colorectal cancer (CRC) and to elucidate its impact on cancer progression.

Results

A notable and statistically significant decrease in the expression levels of hsa_circ_0004194 was observed specifically within CRC tissues when compared to non-tumor colorectal mucosa tissues. Functional evaluations, such as CCK8 assays, plate clone formation analysis, and transwell migration assays, our study revealed hsa_circ_0004194 significantly reduced the activity behavior of CRC cells. This overexpression of hsa_circ_0004194 effectively hindered these key cellular processes, demonstrating its role in suppressing the aggressive behaviors of CRC cells. Additio

SUBMITTER: Chen L 

PROVIDER: S-EPMC11532888 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature