Low toxicity of dissolved silver from silver-coated titanium dental implants to human primary osteoblast cells.

ABSTRACT: the controlled release of silver as a biocide from Ag-coated medical implants is desirable. However, the biocompatibility of Ag leachates is poorly understood. This study investigated the toxicity of silver released from the silver plated titanium implants to human primary osteoblast cells; and the effect of cell culture medium on the silver speciation and bioavailability.

Methods

Ti6Al4V discs were coated with Ag nanoparticles (NPs), silver plus hydroxyapatite (HA) nanoparticles (Ag+nHA), or Ag NPs plus microparticles (Ag+mHA). Primary human osteoblast cells were exposed to the leachates from the various discs for up to 7 days.

Results

the total Ag concentrations released as leachate from the silver-plated titanium discs were 0.7-1.6 mg L^-1, regardless of treatmen

SUBMITTER: Salaie RN 

PROVIDER: S-EPMC11532920 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature