Cell surface morphology mimicking nano-bio platform for immune cell stimulation.

ABSTRACT: Studying the complex realm of cellular communication and interactions by fluorescence microscopy requires sample fixation on a transparent substrate. To activate T cells, which are pivotal in controlling the immune system, it is important to present the activating antigen in a spatial arrangement similar to the nature of the antigen-presenting cell, including the presence of ligands on microvilli. Similar arrangement is predicted for some other immune cells. In this work, immune cell-stimulating platform based on nanoparticle-ligand conjugates have been developed using a scalable, affordable, and broadly applicable technology, which can be readily deployed without the need for state-of-the-art nanofabrication instruments. The validation of surface biofunctionalization was performed by comb

SUBMITTER: Varghese B 

PROVIDER: S-EPMC11532961 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature