Iron load in the normal aging brain measured with QSM and R 2 * at 7T: findings of the SENIOR cohort.

ABSTRACT:

Background

Iron accumulates in the brain during aging and is the focus of intensive research as an abnormal load, particularly in Deep Gray Matter (DGM), is related to neurodegeneration. Magnetic Resonance Imaging (MRI) metrics such as Quantitative Susceptibility Mapping (QSM) and apparent transverse relaxation rate R2* can be used to follow up iron in vivo. While the influence of age and sex on iron levels has already been reported, a careful consideration of neuronal risk factors, as well as for an enhanced sensitivity, is needed to define the normal evolution.

Methods

QSM and R2* at ultra-high field MRI are used to study iron in DGM using a carefully-characterized cohort of the healthy aging brain (SENIOR). Seventy-seven cognitively healthy elders (from 54 to 78 y/

SUBMITTER: Guevara M 

PROVIDER: S-EPMC11533018 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature