High risk of multiple gastric cancers in Japanese individuals with Lynch syndrome.

ABSTRACT:

Aim

Lynch syndrome (LS) is a dominantly inherited syndrome characterized by an increased risk for LS associated tumors such as colorectal cancer (CRC) and gastric cancer (GC). However, the clinical benefit of surveillance for GC remains unclear while it has already been recommended for CRC. This study aimed to elucidate the clinical features of GC in Japanese individuals with LS, and the risk of developing multiple GCs to build regional-tailored surveillance programs in LS patients with GC.

Methods

Data on Japanese individuals with LS were retrospectively collected from a single institution. The clinical features of GC, including the cumulative risk of multiple GCs, were analyzed.

Results

Among 96 individuals with LS (MLH1/MSH2/MSH6, 75:20:1), 32

SUBMITTER: Kanaya N 

PROVIDER: S-EPMC11533028 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature