In Vivo Assessment on Freeze-Cast Calcium Phosphate-Based Scaffolds with a Selective Cell/Tissue Ingrowth.

ABSTRACT: Highly porous bioceramic scaffolds are widely used as bone substitutes in many applications. However, the use of bioceramics is often limited to hard tissues due to the risk of potential soft tissue calcification. A further limitation of highly porous bioceramic scaffolds is their poor mechanical stability, manifested by their tendency to break under stress. In our study, highly porous CaP-based scaffolds were prepared via freeze-casting with longitudinal and oriented pores ranging from 10 to 20 μm and a relative porosity of ∼70%. The resulting scaffolds achieved a flexural strength of 10.6 ± 2.7 MPa, which, in conjunction with their favorable bioactivity, made them suitable for in vivo testing. The prepared scaffolds were subcutaneously implanted in rats for two distinct periods: 6 weeks

SUBMITTER: Pejchalova L 

PROVIDER: S-EPMC11533149 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature