A Molecular View into the Structure and Dynamics of Phase-Separated Chromatin.

ABSTRACT: The organization of chromatin is critical for gene expression, yet the underlying mechanisms responsible for this organization remain unclear. Recent work has suggested that phase separation might play an important role in chromatin organization, yet the molecular forces that drive chromatin phase separation are poorly understood. In this work we interrogate a molecular model of chromatin to quantify the driving forces and thermodynamics of chromatin phase separation. By leveraging a multiscale approach, our molecular model is able to reproduce chromatin's chemical and structural details at the level of a few nanometers, yet remain efficient enough to simulate chromatin phase separation across 100 nm length scales. We first demonstrate that our model can reproduce key experiments of phase

SUBMITTER: Golembeski A 

PROVIDER: S-EPMC11533178 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature